Collagen, Juverderm, Restylane, Radiesse And Sculptra Cost And Comparison

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September 29, 2022

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With all the lip and wrinkle fillers out there it is hard to know which on will be best for you. Is it collagen or Juvederm, maybe Restylane or Radiesse and what’s that Sculptra stuff all about? I have created this short list to help you compare the cost, effectiveness and side effects of these products and determine which one is best for you.

 

Collagen:

This is the original filler. It spreads beautifully and is one of the few products that can fill very fine lines. Unlike like the original Zyderm and Zyplast which required skin testing, newer collages such as Cosmoderm and Cosmoplast do not. The major drawback to collagen is although it is about the same price per unit as all of the other options listed hear it only last about 3 months. Each syringe contains about 1cc of product. Price is about $500-$600 per syringe.

 

Restylane:

Restylane was one of the first of a new type of fillers call Hyaluronic Acids or HAs for short. The clear gel is made of crosslinked HA which can hold up to 1000 times its own weight in water. HAs are naturally found in the skin and would normally breakdown quite quickly but due to its crosslinking, Restylane normally last about 6 months. It can be used just about anywhere including the lips. Another nice thing about all HAs, the product can be removed in a matter of hours if necessary with an enzyme call hyaluronidase which digests the HAs. Each syringe contains 0.8cc of product. Cost is about $500-$600 per syringe.

 

Juvederm:

Juvederm is a second generation HA. It has higher crosslinking so it last a bit longer than Restylane, normally about 9 months. Juvederm is also a smooth gel which makes it less likely to look lumpy under the skin. Both Juvederm and Restylane are about the same cost. Each syringe contains 0.8cc of product. Price is about $500-$600 per syringe.

 

Radiesse:

Radiesse is made of Calcium Hydroxylapatite which is a natural mineral in your own body. This is what we call a collagen stimulating product. That means that not only does the product increase volume but it also stimulates your own tissue to produce more collagen. Radiesse is good for deeper lines and for those that want a longer lasting treatment. This product is NOT appropriate for the lips or fine lines. Radiesse normally last about one year and may require a small touch up around 3-6 months. Rarely patients have had mild allergic reaction to Radiesse which show up a prolonged redness over the injection site. Per unit Radiesse is about the same price a Juvederm and Restylane for a 0.8cc syringe but it also comes in larger volumes of 1.5cc (almost 90% more product for only about 40% cost). Cost is about $500-$800 per syringe.

 

Sculptra:

Sculptra is solely a stimulatory filler. In other words, one does not notice a change from the product itself but rather from the increased tissue collagen that is produced gradually over time after the produce has been placed. Sculptra just received its cosmetic FDA approval in July 2009 but has been used for cosmetic purposed for over 5 years. This product is made of Poly-L-Lactic Acid or PLLA for short. This is same stuff we make absorbable stiches out of so we know it is very safe. Sculptra takes about 3-6 months to do its job but it lasts over three years in many cases. This product normally takes 3 injection sessions spaced about 6-8 weeks apart. It is best for those that need deep volume throughout the face. Side effects can include small papules under the skin if the product is not placed, spread or massaged properly. Cost is about $1200 per treatment.

 

All of these products are broken down fully by the body unlike Silicone, Artecol and Artefill which should be avoided in most cases.

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Colorado's Vascular & Aesthetic Medicine

Stay Informed, Stay Healthy

Explore expert tips, guides, and the latest updates on vein health and treatments.

Danielle Killingsworth, NCMA, Aesthetics Coordinator at Colorado Skin & Vein in Denver

Danielle Killingsworth

NCMA, Aesthetics Coordinator

Danielle is a Colorado native who brings more than 22 years of experience in the medical field. Throughout her career she has developed a diverse clinical background across infectious disease, general surgery, and pain management — giving her a well-rounded understanding of patient care and of what it takes to create a safe, comfortable, and personalized experience.

As Aesthetics Coordinator at Colorado Skin & Vein, Danielle combines that clinical knowledge with a genuine passion for aesthetics. She is dedicated to helping patients feel confident, informed, and supported throughout their aesthetic journey, from the initial consultation through treatment and follow-up care.

She believes one of the most rewarding parts of her career is building meaningful relationships with patients and helping them look and feel their very best.

Outside of work, Danielle enjoys spending time with her family, including her four boys, getting lost in a good book, and working in her garden. Fun fact: she is a dedicated Dallas Cowboys fan.

Nikki Moyta, Operations Director at Colorado Skin & Vein in Denver

Nikki Moyta

Operations Director

For over 26 years, Nikki has dedicated her career to the dermatology and aesthetics industry, building her experience from the ground up — starting in a patient scheduling call center, moving to the front desk, and rising to executive leadership overseeing multiple providers and locations.

Originally from Pittsburgh, she moved to Orlando before starting 10th grade and later attended Seminole State College of Florida. Her career in dermatology began in 2002, scheduling appointments for a multi-location practice. She grew quickly within the organization, moving into front-desk and checkout roles before being promoted to Office Manager in 2008. In 2012, her leadership and operational expertise led the CEO to seek her out for an expanded role overseeing multiple providers and locations — a position she held through 2022.

Outside of her professional career, Nikki is passionate about giving back to the community:

  • Community outreach
  • Voted “Cheerleader of the Practice”
  • 1st Place Winner — Miles for Melanoma

With a career built on leadership, dedication, and a genuine passion for patients and the aesthetics industry, she is excited to bring her experience and enthusiasm to the Colorado community. When she is not in the office, you can find Nikki with her Siberian husky, Compass, somewhere on top of a mountain.

Betina Lacson, RVT at Colorado Skin & Vein in Denver

Betina Lacson

RVT

Betina graduated from the Cardiovascular Technology Program at Grossmont College in California in 2020, and brings more than six years of experience in the duplex world of venous insufficiency. Much of her career has centered on superficial vein mapping and assisting in surgery while providing attentive patient care.

At Colorado Skin & Vein, she assists with venous ablation procedures as well as ultrasound-guided sclerotherapy. She is committed to quality care at every stage — from the initial consultation, through surgery, to post-operative appointments — making sure each patient feels fully supported.

In her free time, Betina loves Kizomba dancing with her Afro-Latin dance community, and can often be found at electronic dance music shows in different cities. If you are feeling generous, she will happily accept a karaoke room or an iced Thai milk tea.

Brooke Owens, PA-C, MPAS at Colorado Skin & Vein in Denver

Brooke Owens

PA-C, MPAS

Brooke Owens, PA-C, MPAS is a compassionate Physician Assistant who brings a strong clinical foundation, exceptional attention to detail, and a patient-centered approach to Colorado Skin & Vein.

Prior to joining the practice, Brooke spent several years in pediatric primary care, caring for patients with a wide range of acute and chronic conditions. She became known for her thorough evaluations, thoughtful clinical decision-making, and ability to build lasting relationships with patients and their families. That experience strengthened her diagnostic expertise while reinforcing the importance of listening carefully, educating patients, and creating individualized treatment plans.

Drawn to the unique blend of medicine, procedures, and patient transformation, Brooke was excited to move into vascular medicine and aesthetic care. She is passionate about helping patients improve not only their health but also their confidence — whether they are seeking treatment for vein disease, skin concerns, or cosmetic enhancements. By combining broad medical experience with advanced specialty training and a meticulous eye for detail, she delivers safe, effective, and personalized care.

Brooke believes the best outcomes begin with trust. She values taking the time to understand each patient’s goals, answer questions, and ensure they feel informed and comfortable throughout their care.

Angel Croce, Staff Manager at Colorado Skin & Vein in Denver

Angel Croce

Staff Manager

Angel has been in healthcare for more than 20 years. Her journey began in 2004, after her father suddenly passed away from a stroke. Losing him was a life-changing experience, and it inspired her to choose a career where she could help others and give patients and their families the care, compassion, and support they need during difficult times.

Throughout her career she has worked across cardiology, neurology, family practice, and urgent care — each experience helping her grow both personally and professionally. She now works in vascular care and aesthetics, where she enjoys building relationships with her patients, helping them understand their care, and making sure they feel comfortable and supported throughout their journey.

Outside of work, Angel is a proud mom of two. Family is incredibly important to her, and in her spare time she loves being outdoors with her husband and their two dogs — hunting, fishing, and enjoying Colorado.

For Angel, healthcare is more than a career — it is personal. What started as a way to honor her father’s memory has become more than two decades of caring for others, and she is grateful to keep doing something that means so much to her every day.