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Unraveling the Mysteries of Restless Leg Syndrome: Causes, Symptoms, and Treatment Options

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July 11, 2024

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coloradoskin1

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Imagine the frustration of an uncontrollable urge to move your legs, often accompanied by uncomfortable sensations, just as you\’re trying to relax or fall asleep. This is the reality for millions of people worldwide who suffer from Restless Leg Syndrome (RLS), a complex disorder that can significantly impact quality of life. In this article, we\’ll dive deep into the potential causes of RLS, explore common symptoms, and discuss effective treatment options, including the connection between RLS and varicose veins.

 

Understanding Restless Leg Syndrome

Restless Leg Syndrome is a disorder characterized by an irresistible urge to move the legs, usually accompanied by unpleasant sensations like tingling, aching, or crawling. RLS affects an estimated 10-15% of the U.S. population, with women being more likely to experience symptoms than men. The condition can occur at any age but is most common in middle-aged and older adults. RLS can significantly impact quality of life, causing sleep disturbances, fatigue, and difficulty concentrating.

 

Potential Causes of Restless Leg Syndrome

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While the exact cause of RLS still being studies, several factors have been identified as potential contributors. Genetic factors play a role, with up to 50% of RLS cases having a family history of the condition. Up to 80% of people who have varicose veins also have Restless Leg Syndrome.  

 

Other causes include iron deficiency anemia have also been linked to RLS, as iron is crucial for proper dopamine function in the brain. Pregnancy, particularly in the third trimester, can trigger RLS symptoms, which often resolve after delivery. Chronic medical conditions such as Parkinson\’s disease, kidney disease, and diabetes may also increase the risk of developing RLS. Certain medications, including antidepressants and antihistamines, have been known to exacerbate RLS symptoms. 

 

The Varicose Vein Connection

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Recent studies have shown that varicose veins, a common condition characterized by enlarged, twisted veins, may contribute to the development of RLS. Varicose veins occur when the valves in the veins become weakened or stretched, causing the valve to not close properly.  This allows blood to fall back down and stretch the vein walls causing varicosities.  This impaired circulation can lead to nerve compression, which may trigger the uncomfortable sensations and urge to move associated with RLS.

 

Dr. David Verebelyi, a leading vein specialist at Colorado Skin & Vein, explains, \”Many patients are surprised to learn that their restless legs may be connected to underlying vein issues but 80% of people with venous reflux also have RLS symptoms.  63% of patients who receive treatment for their vein issues have significant or complete relief of their RLS symptoms.\”

 

Several studies support the link between venous insufficiency and RLS. A study published in the journal Phlebology found that patients with RLS had a higher prevalence of varicose veins compared to those without RLS. Another study in the journal Dermatologic Surgery reported that treating varicose veins with sclerotherapy resulted in significant improvement of RLS symptoms.

 

Diagnosing and Treating Restless Leg Syndrome

Diagnosing RLS involves a thorough evaluation of symptoms and medical history. The International Restless Legs Syndrome Study Group has established five diagnostic criteria, including an urge to move the legs, onset or worsening of symptoms during rest, relief with movement, and occurrence primarily in the evening or night.

 

Treatment for RLS often begins with lifestyle changes, such as regular exercise, maintaining good sleep hygiene, and avoiding triggers like caffeine and alcohol. Sometimes medications, including dopaminergic agents like ropinirole and pramipexole, and gabapentin, may be prescribed to manage symptoms. However, for patients with RLS and varicose veins, addressing the underlying venous issues can be a critical step in finding relief.  All patients with RLS should rule out venous reflux as the cause.

 

Dr. Verebelyi notes, \”At Colorado Skin & Vein, we take a comprehensive approach to treating RLS, addressing underlying venous issues when present to provide optimal relief for our patients.\”

 

Vein treatments such as sclerotherapy, which involves injecting a solution to seal off damaged veins, and endovenous ablation, which uses heat to close off damaged veins, have been shown to improve RLS symptoms in the vast majority of patients.  Colorado Skin & Vein offers state-of-the-art vein treatments in a comfortable, spa-like setting, with a focus on personalized care and patient satisfaction.

Getting Permanent Relief from RLS

Restless Leg Syndrome is a complex condition with multiple potential causes, including genetic factors, vascular issues,  iron deficiency, and underlying medical conditions. The link between RLS and varicose veins is an important consideration in diagnosing and treating this disorder. By identifying and addressing contributing factors like venous insufficiency, patients can find significant relief from the disruptive symptoms of RLS.

 

Dr. Verebelyi encourages those struggling with restless legs to seek help: \”If you\’re struggling with restless legs, know that you\’re not alone and that effective treatments are available. Don\’t hesitate to talk to your doctor or a vein specialist to start your journey towards better sleep and improved quality of life.\”

 

If you suspect that varicose veins may be contributing to your RLS symptoms, consider scheduling a consultation with the experts at Colorado Skin & Vein. Their team of experienced vein specialists can help you develop a personalized treatment plan to address your unique needs and help you find relief from the frustrating symptoms of Restless Leg Syndrome.

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Danielle Killingsworth, NCMA, Aesthetics Coordinator at Colorado Skin & Vein in Denver

Danielle Killingsworth

NCMA, Aesthetics Coordinator

Danielle is a Colorado native who brings more than 22 years of experience in the medical field. Throughout her career she has developed a diverse clinical background across infectious disease, general surgery, and pain management — giving her a well-rounded understanding of patient care and of what it takes to create a safe, comfortable, and personalized experience.

As Aesthetics Coordinator at Colorado Skin & Vein, Danielle combines that clinical knowledge with a genuine passion for aesthetics. She is dedicated to helping patients feel confident, informed, and supported throughout their aesthetic journey, from the initial consultation through treatment and follow-up care.

She believes one of the most rewarding parts of her career is building meaningful relationships with patients and helping them look and feel their very best.

Outside of work, Danielle enjoys spending time with her family, including her four boys, getting lost in a good book, and working in her garden. Fun fact: she is a dedicated Dallas Cowboys fan.

Nikki Moyta, Operations Director at Colorado Skin & Vein in Denver

Nikki Moyta

Operations Director

For over 26 years, Nikki has dedicated her career to the dermatology and aesthetics industry, building her experience from the ground up — starting in a patient scheduling call center, moving to the front desk, and rising to executive leadership overseeing multiple providers and locations.

Originally from Pittsburgh, she moved to Orlando before starting 10th grade and later attended Seminole State College of Florida. Her career in dermatology began in 2002, scheduling appointments for a multi-location practice. She grew quickly within the organization, moving into front-desk and checkout roles before being promoted to Office Manager in 2008. In 2012, her leadership and operational expertise led the CEO to seek her out for an expanded role overseeing multiple providers and locations — a position she held through 2022.

Outside of her professional career, Nikki is passionate about giving back to the community:

  • Community outreach
  • Voted “Cheerleader of the Practice”
  • 1st Place Winner — Miles for Melanoma

With a career built on leadership, dedication, and a genuine passion for patients and the aesthetics industry, she is excited to bring her experience and enthusiasm to the Colorado community. When she is not in the office, you can find Nikki with her Siberian husky, Compass, somewhere on top of a mountain.

Betina Lacson, RVT at Colorado Skin & Vein in Denver

Betina Lacson

RVT

Betina graduated from the Cardiovascular Technology Program at Grossmont College in California in 2020, and brings more than six years of experience in the duplex world of venous insufficiency. Much of her career has centered on superficial vein mapping and assisting in surgery while providing attentive patient care.

At Colorado Skin & Vein, she assists with venous ablation procedures as well as ultrasound-guided sclerotherapy. She is committed to quality care at every stage — from the initial consultation, through surgery, to post-operative appointments — making sure each patient feels fully supported.

In her free time, Betina loves Kizomba dancing with her Afro-Latin dance community, and can often be found at electronic dance music shows in different cities. If you are feeling generous, she will happily accept a karaoke room or an iced Thai milk tea.

Brooke Owens, PA-C, MPAS at Colorado Skin & Vein in Denver

Brooke Owens

PA-C, MPAS

Brooke Owens, PA-C, MPAS is a compassionate Physician Assistant who brings a strong clinical foundation, exceptional attention to detail, and a patient-centered approach to Colorado Skin & Vein.

Prior to joining the practice, Brooke spent several years in pediatric primary care, caring for patients with a wide range of acute and chronic conditions. She became known for her thorough evaluations, thoughtful clinical decision-making, and ability to build lasting relationships with patients and their families. That experience strengthened her diagnostic expertise while reinforcing the importance of listening carefully, educating patients, and creating individualized treatment plans.

Drawn to the unique blend of medicine, procedures, and patient transformation, Brooke was excited to move into vascular medicine and aesthetic care. She is passionate about helping patients improve not only their health but also their confidence — whether they are seeking treatment for vein disease, skin concerns, or cosmetic enhancements. By combining broad medical experience with advanced specialty training and a meticulous eye for detail, she delivers safe, effective, and personalized care.

Brooke believes the best outcomes begin with trust. She values taking the time to understand each patient’s goals, answer questions, and ensure they feel informed and comfortable throughout their care.

Angel Croce, Staff Manager at Colorado Skin & Vein in Denver

Angel Croce

Staff Manager

Angel has been in healthcare for more than 20 years. Her journey began in 2004, after her father suddenly passed away from a stroke. Losing him was a life-changing experience, and it inspired her to choose a career where she could help others and give patients and their families the care, compassion, and support they need during difficult times.

Throughout her career she has worked across cardiology, neurology, family practice, and urgent care — each experience helping her grow both personally and professionally. She now works in vascular care and aesthetics, where she enjoys building relationships with her patients, helping them understand their care, and making sure they feel comfortable and supported throughout their journey.

Outside of work, Angel is a proud mom of two. Family is incredibly important to her, and in her spare time she loves being outdoors with her husband and their two dogs — hunting, fishing, and enjoying Colorado.

For Angel, healthcare is more than a career — it is personal. What started as a way to honor her father’s memory has become more than two decades of caring for others, and she is grateful to keep doing something that means so much to her every day.