Causes Of Restless Leg Syndrome

June 21, 2022

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If you’re familiar with restless leg syndrome, you know just how frustrating – and painful – it can be. Restless leg syndrome doesn’t just impact your legs either; it impacts your ability to fall and stay asleep, which can have detrimental effects on you and your life. But what exactly causes restless leg syndrome? Below, we’ll go over what restless leg syndrome is, what causes restless leg syndrome, what the symptoms of restless leg syndrome are, and restless leg syndrome treatment.

What is Restless Leg Syndrome?

Restless leg syndrome, also called Willis-Ekbom disease, is a nervous system disorder that causes you to experience an intense and uncontrollable urge to move your legs. It usually happens when you’re sleeping or sitting or lying down for an extended period of time. Restless leg syndrome usually happens before bed and can prevent you from falling asleep, staying asleep, and getting quality rest, which has led doctors to classify it as a sleep disorder as well. People who have restless leg syndrome also typically suffer from varicose veins, which are enlarged blood vessels that cause veins in the legs to swell and are often painful.

What Causes Restless Leg Syndrome?

The cause of restless leg syndrome isn’t always known, however, there are a few known causes and triggers.

1. Genetics: Restless leg syndrome can run in your family, and this is often believed to be the cause if symptoms present themselves before the age of 40. Scientists have found a chromosome that has specific sites where restless leg syndrome genes can present themselves as well.

2. Dopamine dysregulation: Scientists have also found that restless leg syndrome is related to the area of the brain called the basal ganglia. The basal ganglia controls movement and muscle function with the neurotransmitter dopamine. Dopamine helps your nervous system regulate and control movement by communicating between the brain and nervous system. If nerve cells in your brain have sustained damage, the amount of dopamine present in your brain becomes reduced, which results in involuntary movement and muscle spasms. Dopamine levels naturally taper off at the end of the day, and this is why it’s believed that restless leg syndrome symptoms are worse at night.

3. Iron deficiency: It’s not entirely clear how iron deficiency or anemia plays a part in restless leg syndrome, but there is a connection between the two. Iron deficiency affects other areas of the brain, and it’s believed that this could impact dopamine regulation.

4. Chronic diseases: Some chronic and long-term diseases include restless leg syndrome as a symptom. These include Parkinson’s disease, kidney failure/renal disease, diabetes, rheumatoid arthritis, hypothyroidism, fibromyalgia, and peripheral neuropathy (nerve damage).

5. Pregnancy: The hormonal changes that occur during pregnancy, especially during the third trimester, can trigger the onset of restless leg syndrome or make existing restless leg syndrome worse. Pregnancy-related restless leg syndrome typically goes away following the pregnancy.

6. Medications: Some medicines can make symptoms worse or trigger restless leg syndrome while in use. These include antipsychotics, some antidepressants, cold and allergy meds that contain antihistamines, and anti-nausea meds.

7. Lifestyle: Certain lifestyle factors are restless leg syndrome causes. A lack of sleep, sleep disorders like sleep apnea, being overweight, chronic stress, excessive alcohol and/or caffeine consumption, and smoking are all linked to restless leg syndrome.

What are Restless Leg Syndrome Symptoms?

There are five basic criteria and symptoms that must be present to diagnose restless leg syndrome. They are:

  • An uncontrollable and overwhelming urge to move your legs that feels painful or uncomfortable
  • The urge to move starts or gets worse during times of rest
  • The urge to move starts or gets worse at nighttime
  • The urge dissipates with movement
  • There’s no other cause of the urge to move, such as leg cramps, muscle spasms, or arthritis

What Are Restless Leg Syndrome Treatment Options?

Unfortunately, there is no cure for restless leg syndrome but, there are treatment options that can help you manage symptoms. The restless leg syndrome treatments include:

  • Getting regular exercise
  • Following a sleep schedule
  • Avoiding alcohol, caffeine, and smoking
  • Leg massages
  • Hot baths
  • Heating and ice packs
  • Dopaminergic drugs
  • Benzodiazepines
  • Magnesium supplements
  • Anti-seizure meds
  • Narcotic pain relievers

Restless leg syndrome is a lifelong disease that can be difficult to live with. Working with your doctor to understand what might cause or trigger your restless leg syndrome is the best way to manage your symptoms. To learn more about restless leg syndrome or to seek treatment for varicose veins that might be making your restless leg syndrome worse, contact us today!

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Danielle Killingsworth, NCMA, Aesthetics Coordinator at Colorado Skin & Vein in Denver

Danielle Killingsworth

NCMA, Aesthetics Coordinator

Danielle is a Colorado native who brings more than 22 years of experience in the medical field. Throughout her career she has developed a diverse clinical background across infectious disease, general surgery, and pain management — giving her a well-rounded understanding of patient care and of what it takes to create a safe, comfortable, and personalized experience.

As Aesthetics Coordinator at Colorado Skin & Vein, Danielle combines that clinical knowledge with a genuine passion for aesthetics. She is dedicated to helping patients feel confident, informed, and supported throughout their aesthetic journey, from the initial consultation through treatment and follow-up care.

She believes one of the most rewarding parts of her career is building meaningful relationships with patients and helping them look and feel their very best.

Outside of work, Danielle enjoys spending time with her family, including her four boys, getting lost in a good book, and working in her garden. Fun fact: she is a dedicated Dallas Cowboys fan.

Nikki Moyta, Operations Director at Colorado Skin & Vein in Denver

Nikki Moyta

Operations Director

For over 26 years, Nikki has dedicated her career to the dermatology and aesthetics industry, building her experience from the ground up — starting in a patient scheduling call center, moving to the front desk, and rising to executive leadership overseeing multiple providers and locations.

Originally from Pittsburgh, she moved to Orlando before starting 10th grade and later attended Seminole State College of Florida. Her career in dermatology began in 2002, scheduling appointments for a multi-location practice. She grew quickly within the organization, moving into front-desk and checkout roles before being promoted to Office Manager in 2008. In 2012, her leadership and operational expertise led the CEO to seek her out for an expanded role overseeing multiple providers and locations — a position she held through 2022.

Outside of her professional career, Nikki is passionate about giving back to the community:

  • Community outreach
  • Voted “Cheerleader of the Practice”
  • 1st Place Winner — Miles for Melanoma

With a career built on leadership, dedication, and a genuine passion for patients and the aesthetics industry, she is excited to bring her experience and enthusiasm to the Colorado community. When she is not in the office, you can find Nikki with her Siberian husky, Compass, somewhere on top of a mountain.

Betina Lacson, RVT at Colorado Skin & Vein in Denver

Betina Lacson

RVT

Betina graduated from the Cardiovascular Technology Program at Grossmont College in California in 2020, and brings more than six years of experience in the duplex world of venous insufficiency. Much of her career has centered on superficial vein mapping and assisting in surgery while providing attentive patient care.

At Colorado Skin & Vein, she assists with venous ablation procedures as well as ultrasound-guided sclerotherapy. She is committed to quality care at every stage — from the initial consultation, through surgery, to post-operative appointments — making sure each patient feels fully supported.

In her free time, Betina loves Kizomba dancing with her Afro-Latin dance community, and can often be found at electronic dance music shows in different cities. If you are feeling generous, she will happily accept a karaoke room or an iced Thai milk tea.

Brooke Owens, PA-C, MPAS at Colorado Skin & Vein in Denver

Brooke Owens

PA-C, MPAS

Brooke Owens, PA-C, MPAS is a compassionate Physician Assistant who brings a strong clinical foundation, exceptional attention to detail, and a patient-centered approach to Colorado Skin & Vein.

Prior to joining the practice, Brooke spent several years in pediatric primary care, caring for patients with a wide range of acute and chronic conditions. She became known for her thorough evaluations, thoughtful clinical decision-making, and ability to build lasting relationships with patients and their families. That experience strengthened her diagnostic expertise while reinforcing the importance of listening carefully, educating patients, and creating individualized treatment plans.

Drawn to the unique blend of medicine, procedures, and patient transformation, Brooke was excited to move into vascular medicine and aesthetic care. She is passionate about helping patients improve not only their health but also their confidence — whether they are seeking treatment for vein disease, skin concerns, or cosmetic enhancements. By combining broad medical experience with advanced specialty training and a meticulous eye for detail, she delivers safe, effective, and personalized care.

Brooke believes the best outcomes begin with trust. She values taking the time to understand each patient’s goals, answer questions, and ensure they feel informed and comfortable throughout their care.

Angel Croce, Staff Manager at Colorado Skin & Vein in Denver

Angel Croce

Staff Manager

Angel has been in healthcare for more than 20 years. Her journey began in 2004, after her father suddenly passed away from a stroke. Losing him was a life-changing experience, and it inspired her to choose a career where she could help others and give patients and their families the care, compassion, and support they need during difficult times.

Throughout her career she has worked across cardiology, neurology, family practice, and urgent care — each experience helping her grow both personally and professionally. She now works in vascular care and aesthetics, where she enjoys building relationships with her patients, helping them understand their care, and making sure they feel comfortable and supported throughout their journey.

Outside of work, Angel is a proud mom of two. Family is incredibly important to her, and in her spare time she loves being outdoors with her husband and their two dogs — hunting, fishing, and enjoying Colorado.

For Angel, healthcare is more than a career — it is personal. What started as a way to honor her father’s memory has become more than two decades of caring for others, and she is grateful to keep doing something that means so much to her every day.